Azetidin-3-ol hydrochloride
Azetidin-3-ol hydrochloride structure
|
Common Name | Azetidin-3-ol hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 18621-18-6 | Molecular Weight | 109.555 | |
| Density | N/A | Boiling Point | 170.7ºC at 760 mmHg | |
| Molecular Formula | C3H8ClNO | Melting Point | 90-92°C | |
| MSDS | Chinese USA | Flash Point | 120.4ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
Use of Azetidin-3-ol hydrochlorideAzetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC. |
| Name | azetidin-3-ol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Boiling Point | 170.7ºC at 760 mmHg |
|---|---|
| Melting Point | 90-92°C |
| Molecular Formula | C3H8ClNO |
| Molecular Weight | 109.555 |
| Flash Point | 120.4ºC |
| Exact Mass | 109.029442 |
| PSA | 32.26000 |
| LogP | 0.08130 |
| Vapour Pressure | 0.464mmHg at 25°C |
| Storage condition | Room temperature. |
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | C,Xi,Xn |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
|
~99%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: Isoda, Takeshi; Ushirogochi, Hideki; Satoh, Koichi; Takasaki, Tsuyoshi; Yamamura, Itsuki; Sato, Chisato; Mihira, Ado; Abe, Takao; Tamai, Satoshi; Yamamoto, Shigeki; Kumagai, Toshio; Nagao, Yoshimitsu Journal of Antibiotics, 2006 , vol. 59, # 4 p. 241 - 247 |
|
~67%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: Adams, Jerry L.; Boehm, Jeffrey C.; Hall, Ralph; Jin, Qi; Kasparec, Jiri; Silva, Domingos J.; Taggart, John J. Patent: US2004/116697 A1, 2004 ; Location in patent: Page 82 ; US 20040116697 A1 |
|
~%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: WO2006/15194 A2, ; Page/Page column 14 ; |
|
~%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: WO2005/118572 A1, ; Page/Page column 198 ; WO 2005/118572 A1 |
|
~87%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: Krishna Reddy; Udaykiran; Chintamani; Mahesh Reddy; Kameswararao, Ch.; Madhusudhan Organic Process Research and Development, 2011 , vol. 15, # 2 p. 462 - 466 |
|
~99%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: Dave, Paritosh R. Journal of Organic Chemistry, 1996 , vol. 61, # 16 p. 5453 - 5455 |
|
~%
Azetidin-3-ol h... CAS#:18621-18-6 |
| Literature: Tetrahedron Letters, , vol. 40, # 19 p. 3761 - 3764 |
![1-Azabicyclo[1.1.0]butane structure](https://image.chemsrc.com/caspic/299/19540-05-7.png)
| Precursor 8 | |
|---|---|
| DownStream 6 | |
CAS#:141890-67-7
CAS#:128117-22-6
CAS#:141699-55-0
CAS#:154010-96-5
CAS#:161715-27-1
CAS#:189279-58-1| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
Org. Process Res. Dev. 10 , 803, (2006)
|
| 3-Azetidinol Hydrochloride |
| azetidin-3-ol monohydrochloride |
| MFCD02683887 |
| Azetidin-3-ol hydrochloride |
| 3-hydroxyazetidine monohydrochloride |
| 3-Hydroxyazetidine-HCl |
| azetidin-3-ol-hydrochloride |
| 3-Azetidinol hydrochloride (1:1) |
| 3-Azetidinol, hydrochloride (1:1) |
| 3-hydroxy-1-azetidine hydrochloride |
| azetidin-3-ol hcl |
| 3-Hydroxyazetidine Hydrochloride |
| 3-hydroxyazetidinium chloride |
| 3 HYDROXY AZETIDINE HYDROCHLORIDE |
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