Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Azetidin-3-ol hydrochloride
Price: ￥318.0/25g ￥228.0/5g
Purity: 97.0%
Stocking Period: 2 Day
Contact: Liu jia

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: Azetidin-3-ol hydrochloride
Price: ￥Inquiry/10g
Purity: 98.0%
Stocking Period: 14 Day
Contact: Lihua Yang

DC Chemicals Limited
China
Product Name: Azetidin-3-ol hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Hydroxyazetidine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

18621-18-6

18621-18-6 structure

Name: Azetidin-3-ol hydrochloride
Chemical Name: azetidin-3-ol,hydrochloride
CAS Number: 18621-18-6
Molecular Formula: C₃H₈ClNO
Molecular Weight: 109.555
Catalog: Chemical reagent Organic reagent Imine, hydrazine
Create Date: 2018-02-08 08:00:00
Modify Date: 2024-01-02 10:20:43
Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.

Name	azetidin-3-ol,hydrochloride
Synonyms	3-Azetidinol Hydrochloride azetidin-3-ol monohydrochloride MFCD02683887 Azetidin-3-ol hydrochloride 3-hydroxyazetidine monohydrochloride 3-Hydroxyazetidine-HCl azetidin-3-ol-hydrochloride 3-Azetidinol hydrochloride (1:1) 3-Azetidinol, hydrochloride (1:1) 3-hydroxy-1-azetidine hydrochloride azetidin-3-ol hcl 3-Hydroxyazetidine Hydrochloride 3-hydroxyazetidinium chloride 3 HYDROXY AZETIDINE HYDROCHLORIDE

Description	Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Boiling Point	170.7ºC at 760 mmHg
Melting Point	90-92°C
Molecular Formula	C₃H₈ClNO
Molecular Weight	109.555
Flash Point	120.4ºC
Exact Mass	109.029442
PSA	32.26000
LogP	0.08130
Vapour Pressure	0.464mmHg at 25°C
Storage condition	Room temperature.

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	C,Xi,Xn
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
HS Code	2933990090

90604-02-7

~99%

18621-18-6

Literature: Isoda, Takeshi; Ushirogochi, Hideki; Satoh, Koichi; Takasaki, Tsuyoshi; Yamamura, Itsuki; Sato, Chisato; Mihira, Ado; Abe, Takao; Tamai, Satoshi; Yamamoto, Shigeki; Kumagai, Toshio; Nagao, Yoshimitsu Journal of Antibiotics, 2006 , vol. 59, # 4 p. 241 - 247

7647-01-0

18621-17-5

~67%

18621-18-6

Literature: Adams, Jerry L.; Boehm, Jeffrey C.; Hall, Ralph; Jin, Qi; Kasparec, Jiri; Silva, Domingos J.; Taggart, John J. Patent: US2004/116697 A1, 2004 ; Location in patent: Page 82 ; US 20040116697 A1

54881-13-9

18621-18-6

Literature: WO2006/15194 A2, ; Page/Page column 14 ;

848438-92-6

18621-18-6

Literature: WO2005/118572 A1, ; Page/Page column 198 ; WO 2005/118572 A1

223382-13-6

~87%

18621-18-6

Literature: Krishna Reddy; Udaykiran; Chintamani; Mahesh Reddy; Kameswararao, Ch.; Madhusudhan Organic Process Research and Development, 2011 , vol. 15, # 2 p. 462 - 466

143329-27-5

~99%

18621-18-6

Literature: Dave, Paritosh R. Journal of Organic Chemistry, 1996 , vol. 61, # 16 p. 5453 - 5455

19540-05-7

18621-18-6

Literature: Tetrahedron Letters, , vol. 40, # 19 p. 3761 - 3764

Precursor 8
90604-02-7 7647-01-0 18621-17-5 54881-13-9
848438-92-6 223382-13-6 143329-27-5 19540-05-7
DownStream 6
141890-67-7 128117-22-6 141699-55-0 154010-96-5
161715-27-1 189279-58-1

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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