NS309
Modify Date: 2024-01-02 17:58:03
NS309 structure
|
Common Name | NS309 | ||
|---|---|---|---|---|
| CAS Number | 18711-16-5 | Molecular Weight | 231.036 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C8H4Cl2N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NS309NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.IC50 value: Ca2+-activated K+ channelTarget: |
| Name | 6,7-dichloro-3-(hydroxyamino)indol-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.IC50 value: Ca2+-activated K+ channelTarget: |
|---|---|
| Related Catalog | |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Molecular Formula | C8H4Cl2N2O2 |
| Molecular Weight | 231.036 |
| Exact Mass | 229.964981 |
| PSA | 61.69000 |
| LogP | 2.66 |
| Index of Refraction | 1.742 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933790090 |
| HS Code | 2933790090 |
|---|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
|
Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients.
J. Am. Heart Assoc. 4 , e002062, (2015) Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabe... |
|
|
Duration differences of corticostriatal responses in striatal projection neurons depend on calcium activated potassium currents.
Front. Syst. Neurosci. 7 , 63, (2013) The firing of striatal projection neurons (SPNs) exhibits afterhyperpolarizing potentials (AHPs) that determine discharge frequency. They are in part generated by Ca(2+)-activated K(+)-currents involv... |
|
|
Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats.
Eur. J. Pharmacol. 735 , 68-76, (2014) We have analysed the effects of large-conductance calcium-activated potassium channel (BK) stimulation on neurogenic and myogenic contraction of human bladder from healthy subjects and patients with u... |
| 1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime, (3E)- |
| 6,7-Dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one |
| NS-309 |
| 6,7-dichloro-1H-indole-2,3-dione-3-oxime |
| (3E)-6,7-Dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one |
| 6,7-dichloroisatin 3-oxime |
| 1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime |
| 6,7-Dichloro-1H-indole-2,3-dione 3-oxime |
| 3-Oxime-6,7-dichloro-1H-indole-2,3-dione |
| NS309 |