DD1
Modify Date: 2024-01-10 11:30:36
DD1 structure
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Common Name | DD1 | ||
|---|---|---|---|---|
| CAS Number | 187585-11-1 | Molecular Weight | 282.29400 | |
| Density | 1.337g/cm3 | Boiling Point | 479.2ºC at 760 mmHg | |
| Molecular Formula | C16H14N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 233.6ºC | |
Use of DD1DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1]. |
| Name | 3-amino-2-(3-amino-4-methoxyphenyl)chromen-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1]. |
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| Related Catalog | |
| In Vitro | DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1]. DD1 induces cell cycle arrest at G2/M phase and apoptosis[1]. DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1]. DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1]. |
| References |
| Density | 1.337g/cm3 |
|---|---|
| Boiling Point | 479.2ºC at 760 mmHg |
| Molecular Formula | C16H14N2O3 |
| Molecular Weight | 282.29400 |
| Flash Point | 233.6ºC |
| Exact Mass | 282.10000 |
| PSA | 91.48000 |
| LogP | 3.79540 |
| Vapour Pressure | 2.4E-09mmHg at 25°C |
| Index of Refraction | 1.667 |
| Storage condition | -20°C |
| 3,3'-Diamino-4'-methoxyflavone |
| DD1 |