187585-11-1

187585-11-1 structure

Name: DD1
Chemical Name: 3-amino-2-(3-amino-4-methoxyphenyl)chromen-4-one
CAS Number: 187585-11-1
Molecular Formula: C₁₆H₁₄N₂O₃
Molecular Weight: 282.29400
Catalog: Signaling Pathways MAPK/ERK Pathway Ribosomal S6 Kinase (RSK)
Create Date: 2016-10-19 18:26:53
Modify Date: 2024-01-10 11:30:36
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].

Name	3-amino-2-(3-amino-4-methoxyphenyl)chromen-4-one
Synonyms	3,3'-Diamino-4'-methoxyflavone DD1

Description	DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)
In Vitro	DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1]. DD1 induces cell cycle arrest at G2/M phase and apoptosis[1]. DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1]. DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1].
References	[1]. Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833(6):1316-28.