Paederosidic acid

Modify Date: 2024-01-02 12:03:38

Paederosidic acid Structure
Paederosidic acid structure
Common Name Paederosidic acid
CAS Number 18842-98-3 Molecular Weight 464.441
Density 1.7±0.1 g/cm3 Boiling Point 748.1±70.0 °C at 760 mmHg
Molecular Formula C18H24O12S Melting Point N/A
MSDS N/A Flash Point 406.2±35.7 °C

 Use of Paederosidic acid


Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1].

 Names

Name (1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methyls ulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyr an-4-carboxylic acid
Synonym More Synonyms

 Paederosidic acid Biological Activity

Description Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1].
Related Catalog
Target

IC50: apoptosis[1]

In Vitro Paederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of 40.68, 42.58, and 36.48 μg/ml, respectively[1]. Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells[1]. .
References

[1]. Yu P, et al. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis.Chem Biol Interact. 2017 May 1;269:33-40.

[2]. Chen YF, et al. Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.CNS Neurosci Ther. 2014 Feb;20(2):188-90.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 748.1±70.0 °C at 760 mmHg
Molecular Formula C18H24O12S
Molecular Weight 464.441
Flash Point 406.2±35.7 °C
Exact Mass 464.098846
PSA 217.74000
LogP -1.48
Vapour Pressure 0.0±5.6 mmHg at 25°C
Index of Refraction 1.666

 Synonyms

paederosidic acid
(1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methylsulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid
Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-[[[(methylthio)carbonyl]oxy]methyl]-, (1S,4aS,5S,7aS)-