Tenacissoside H

Modify Date: 2024-01-06 22:41:15

Tenacissoside H Structure
Tenacissoside H structure
Common Name Tenacissoside H
CAS Number 191729-45-0 Molecular Weight 794.965
Density 1.3±0.1 g/cm3 Boiling Point 815.4±65.0 °C at 760 mmHg
Molecular Formula C42H66O14 Melting Point N/A
MSDS N/A Flash Point 235.5±27.8 °C

 Use of Tenacissoside H


Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1]

 Names

Name 12-acetoxy-1-acetyl-8-((5-((3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10a,12a-dimethyltetradecahydro-1H-cyclopenta[1,2]phenanthro[1,10a-b]oxiren-11-yl 2-methylbutanoate
Synonym More Synonyms

 Tenacissoside H Biological Activity

Description Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1]
Related Catalog
References

[1]. Jia YS, et al. Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade. Evid Based Complement Alternat Med. 2015;2015:464937.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 815.4±65.0 °C at 760 mmHg
Molecular Formula C42H66O14
Molecular Weight 794.965
Flash Point 235.5±27.8 °C
Exact Mass 794.445251
PSA 178.04000
LogP 4.73
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.551

 Safety Information

Safety Phrases 24/25
HS Code 29389090

 Synonyms

(3β,5α,11α,12β,14β,17α)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl 2-meth ylbutanoate
Butanoic acid, 2-methyl-, (3β,5α,11α,12β,14β,17α)-12-(acetyloxy)-3-[[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy]-8,14-ep oxy-20-oxopregnan-11-yl ester
Tenacissoside H
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