Tenacissoside H structure
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Common Name | Tenacissoside H | ||
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CAS Number | 191729-45-0 | Molecular Weight | 794.965 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 815.4±65.0 °C at 760 mmHg | |
Molecular Formula | C42H66O14 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 235.5±27.8 °C |
Use of Tenacissoside HTenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1] |
Name | 12-acetoxy-1-acetyl-8-((5-((3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10a,12a-dimethyltetradecahydro-1H-cyclopenta[1,2]phenanthro[1,10a-b]oxiren-11-yl 2-methylbutanoate |
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Synonym | More Synonyms |
Description | Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1] |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 815.4±65.0 °C at 760 mmHg |
Molecular Formula | C42H66O14 |
Molecular Weight | 794.965 |
Flash Point | 235.5±27.8 °C |
Exact Mass | 794.445251 |
PSA | 178.04000 |
LogP | 4.73 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.551 |
Safety Phrases | 24/25 |
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HS Code | 29389090 |
(3β,5α,11α,12β,14β,17α)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl 2-meth ylbutanoate |
Butanoic acid, 2-methyl-, (3β,5α,11α,12β,14β,17α)-12-(acetyloxy)-3-[[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy]-8,14-ep oxy-20-oxopregnan-11-yl ester |
Tenacissoside H |