Co 101244 hydrochloride

Modify Date: 2024-01-13 19:55:00

Co 101244 hydrochloride Structure
Co 101244 hydrochloride structure
Common Name Co 101244 hydrochloride
CAS Number 193356-17-1 Molecular Weight 377.9
Density N/A Boiling Point N/A
Molecular Formula C21H28ClNO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Co 101244 hydrochloride


Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].

 Names

Name 1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)
Synonym More Synonyms

 Co 101244 hydrochloride Biological Activity

Description Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].
Related Catalog
In Vitro Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection[1].
In Vivo Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].
References

[1]. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.

 Chemical & Physical Properties

Molecular Formula C21H28ClNO3
Molecular Weight 377.9
Storage condition -20°C

 Synonyms

4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-, hydrochloride (1:1)
1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidin-4-ol hydrochloride (1:1)
1-[2-(4-Hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)-4-piperidinol hydrochloride (1:1)
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