DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

Modify Date: 2024-01-12 19:31:02

DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2 Structure
DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2 structure
Common Name DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
CAS Number 193475-71-7 Molecular Weight 1325.54
Density N/A Boiling Point N/A
Molecular Formula C63H88N16O14S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2


TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

 Names

Name DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
Synonym More Synonyms

  Biological Activity

Description TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
Related Catalog

 Chemical & Physical Properties

Molecular Formula C63H88N16O14S
Molecular Weight 1325.54
Exact Mass 1309.63000
PSA 459.01000
LogP 8.07790

 Synonyms

tno211
dabcyl-(g-abu)-pqgl-e(edans)ak-nh2
mmp substrate iii,fluorogenic
dabcyl-gaba-pro-gln-gly-leu-glu(edans)-ala-lys-nh2
dabcyl-(g-abu)-pro-gln-gly-leu-glu(edans)-ala-lys-nh2
dabcyl-gaba-pqgl-e(edans)-ak-nh2
DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
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