GRK2-IN-115h hydrochloride
Modify Date: 2024-09-17 03:31:44
GRK2-IN-115h hydrochloride structure
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Common Name | GRK2-IN-115h hydrochloride | ||
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| CAS Number | 1941168-71-3 | Molecular Weight | 502.926 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H22ClF3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GRK2-IN-115h hydrochlorideA highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment. |
| Name | GRK2-IN-115h hydrochloride |
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| Description | A highly potent and selective GRK2 inhibitor with IC50 of 18 nM; showes enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM); potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol; a novel potential agent for heart failure treatment. |
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| References | References 1. Okawa T, et al. J Med Chem. 2017 Aug 24;60(16):6942-6990. View Related Products by Target GRK (GPCRK) |
| Molecular Formula | C24H22ClF3N6O |
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| Molecular Weight | 502.926 |