Thalidomide-PEG3-NH2

Modify Date: 2024-02-03 10:32:00

Thalidomide-PEG3-NH2 Structure
Thalidomide-PEG3-NH2 structure
Common Name Thalidomide-PEG3-NH2
CAS Number 1957236-10-0 Molecular Weight 405.40
Density N/A Boiling Point N/A
Molecular Formula C19H23N3O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-PEG3-NH2


Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

 Names

Name Thalidomide-PEG3-NH2

 Thalidomide-PEG3-NH2 Biological Activity

Description Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-997.

 Chemical & Physical Properties

Molecular Formula C19H23N3O7
Molecular Weight 405.40

 Safety Information

Hazard Codes Xi
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