10-甲氧基喜树碱

• 常用名: 10-甲氧基喜树碱
• 英文名: (4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• CAS号: 19685-10-0
• 分子量: 378.378
• 密度: 1.5±0.1 g/cm3
• 沸点: 773.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₁₈N₂O₅
• 熔点: N/A
• 闪点: 421.4±32.9 °C

10-甲氧基喜树碱用途

10-Methoxycamptothecin 是从喜树 (Camptotheca acuminata) 中分离出的喜树碱 (CPT) 的天然生物活性衍生物,已被证实具有高抗癌特性。通过测定对 2774 细胞系的抗肿瘤活性,发现 10-Methoxycamptothecin 比 10-羟基喜树碱 (10-hydroxycamptothecin) 具有更高的细胞毒性。

10-甲氧基喜树碱名称

• 中文名: 9-甲氧基喜树碱
• 英文名: 9-methoxycamptothecine
• 中文别名: 10-甲氧基喜树碱

10-甲氧基喜树碱生物活性

• 描述: 10-Methoxycamptothecin 是从喜树 (Camptotheca acuminata) 中分离出的喜树碱 (CPT) 的天然生物活性衍生物,已被证实具有高抗癌特性。通过测定对 2774 细胞系的抗肿瘤活性,发现 10-Methoxycamptothecin 比 10-羟基喜树碱 (10-hydroxycamptothecin) 具有更高的细胞毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Zheng J, et al. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:81-7.

10-甲氧基喜树碱物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 773.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₁₈N₂O₅
• 分子量: 378.378
• 闪点: 421.4±32.9 °C
• 精确质量: 378.121582
• PSA: 90.65000
• LogP: 1.69
• InChIKey: KLFJSYOEEYWQMR-NRFANRHFSA-N
• SMILES: CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(OC)ccc3nc2-1
• 蒸汽压: 0.0±2.8 mmHg at 25°C
• 折射率: 1.723
• 储存条件: 2-8C

10-甲氧基喜树碱靶点实验

查看更多实验

实验名称：Compound was evaluated for antitumor activity against P-338 leukemia in mice, active ... 来源：ChEMBL 靶标：P338 External Id：CHEMBL762133

实验名称：Compound was evaluated for antitumor activity against P-338 leukemia in mice at the d... 来源：ChEMBL 靶标：P338 External Id：CHEMBL756447

实验名称：Antitumor activity against P-338 leukemia in mice. 来源：ChEMBL 靶标：P338 External Id：CHEMBL757830

实验名称：Therapeutic index was measured on P-388 leukemia cells. 来源：ChEMBL 靶标：N/A External Id：CHEMBL840236

实验名称：Antitumor activity against P-338 leukemia in mice. 来源：ChEMBL 靶标：P338 External Id：CHEMBL757828

实验名称：Antitumor activity against human A549/ATCC cells by SRB method 来源：ChEMBL 靶标：A549 External Id：CHEMBL1056258

实验名称：Antitumor activity against human HT-29 cells by SRB method 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL1056259

实验名称：This is the dose at which optimal activity was observed against P-388 leukemia cells 来源：ChEMBL 靶标：P388 External Id：CHEMBL757836

实验名称：Antileukemic activity against P-388 leukemia cells was measured at given dose range 来源：ChEMBL 靶标：P388 External Id：CHEMBL757837

实验名称：In vitro cytotoxicity of compound was tested against 9KB cells. 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL620380

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10-甲氧基喜树碱英文别名

• (4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 10-methoxycamptothecin
• 10-MethoxycaMptothecine