XAP 044

Modify Date: 2024-01-09 18:33:40

XAP 044 structure	Common Name	XAP 044
	CAS Number	196928-50-4	Molecular Weight	380.134
	Density	1.9±0.1 g/cm3	Boiling Point	485.7±45.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₉IO₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	247.5±28.7 °C
	Symbol	GHS06	Signal Word	Danger

Use of XAP 044

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].

Name	XAP044
Synonym	More Synonyms

Description	XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Gee CE, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014;289(16):10975-10987.

Density	1.9±0.1 g/cm3
Boiling Point	485.7±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₉IO₄
Molecular Weight	380.134
Flash Point	247.5±28.7 °C
Exact Mass	379.954529
LogP	4.61
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.718