196928-50-4

196928-50-4 structure

Name: XAP 044
Chemical Name: XAP044
CAS Number: 196928-50-4
Molecular Formula: C₁₅H₉IO₄
Molecular Weight: 380.134
Create Date: 2021-01-09 17:35:50
Modify Date: 2024-01-09 18:33:40
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].

Name	XAP044
Synonyms	4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-iodophenoxy)- MFCD00525548 XAP 044 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one XAP044

Description	XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Gee CE, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014;289(16):10975-10987.