Perlapine

Modify Date: 2024-01-10 18:05:40

Perlapine Structure
Perlapine structure
 Common Name Perlapine
CAS Number 1977-11-3 Molecular Weight 291.39000
Density N/A Boiling Point N/A
Molecular Formula C19H21N3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Perlapine


Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer Drugs) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors[1].

 Names

Name 6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
Synonym More Synonyms

 Perlapine Biological Activity

Description Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer Drugs) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors[1].
Related Catalog
References

[1]. Chen X, et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.

 Chemical & Physical Properties

Molecular Formula C19H21N3
Molecular Weight 291.39000
Exact Mass 291.17400
PSA 18.84000
LogP 2.22790
Vapour Pressure 7.74E-08mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HO2840000
CHEMICAL NAME :
11H-Dibenz(b,e)azepine, 6-(4-methyl-1-piperazinyl)-
CAS REGISTRY NUMBER :
1977-11-3
BEILSTEIN REFERENCE NO. :
0434631
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C19-H21-N3
MOLECULAR WEIGHT :
291.43
WISWESSER LINE NOTATION :
T C676 IN BHJ J- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,770,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 11,76,1975

 Synthetic Route

6H-Dibenz[b,e]azepin-6-one,5,11-dihydro- structure

6H-Dibenz[b,e]a...

CAS#:1211-06-9

~%

Perlapine Structure

Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165
Anthrone structure

Anthrone

CAS#:90-44-8

~%

Perlapine Structure

Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165
N-(10H-anthracen-9-ylidene)hydroxylamine structure

N-(10H-anthrace...

CAS#:92560-84-4

~%

Perlapine Structure

Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165
methylpiperazine structure

methylpiperazine

CAS#:109-01-3

6-chloro-11H-dibenz(b,e)azepine structure

6-chloro-11H-di...

CAS#:4998-12-3

~%

Perlapine Structure

Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165

 Synonyms

6-(4-Methyl-1-piperazinyl)morphanthridine
Perlapina [Spanish]
Perlapinum [INN-Latin]
6-(4-Methyl-1-piperazinyl)-morphanthridin
Hypnodin
AW-14'2333
6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine
Morphanthridine,6-(4-methyl-1-piperazinyl)
Perlapin
Perlapina [INN-Spanish]
MP-11
6-(4-Methyl-piperazin-1-yl)-morphanthridin
PERLAPINE
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