Perlapine

Modify Date: 2024-01-10 18:05:40

Perlapine structure	Common Name	Perlapine
	CAS Number	1977-11-3	Molecular Weight	291.39000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₁N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Perlapine

Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer Drugs) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors[1].

Name	6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
Synonym	More Synonyms

Description	Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer Drugs) agonist Perlapine exhibits >10000-fold selectivity for hM3Dq over hM3 receptors[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. Chen X, et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.

Molecular Formula	C₁₉H₂₁N₃
Molecular Weight	291.39000
Exact Mass	291.17400
PSA	18.84000
LogP	2.22790
Vapour Pressure	7.74E-08mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO2840000

CHEMICAL NAME :: 11H-Dibenz(b,e)azepine, 6-(4-methyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 1977-11-3

BEILSTEIN REFERENCE NO. :: 0434631

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H21-N3

MOLECULAR WEIGHT :: 291.43

WISWESSER LINE NOTATION :: T C676 IN BHJ J- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,770,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,193,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 11,76,1975

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Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165

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Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165

N-(10H-anthrace...

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Perlapine

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methylpiperazine

CAS#:109-01-3

6-chloro-11H-di...

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Perlapine

CAS#:1977-11-3

Literature: Sinha, Ashok Kumar; Nizamuddin, S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 165

Precursor 4
CAS#:1211-06-9 6H-Dibenz[b,e]a... CAS#:90-44-8 Anthrone CAS#:92560-84-4 N-(10H-anthrace... CAS#:109-01-3 methylpiperazine
DownStream 0

6-(4-Methyl-1-piperazinyl)morphanthridine

Perlapina [Spanish]

Perlapinum [INN-Latin]

6-(4-Methyl-1-piperazinyl)-morphanthridin

Hypnodin

AW-14'2333

6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine

Morphanthridine,6-(4-methyl-1-piperazinyl)

Perlapin

Perlapina [INN-Spanish]

MP-11

6-(4-Methyl-piperazin-1-yl)-morphanthridin

PERLAPINE

DC Chemicals Limited
China
Product Name: Perlapine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 11H-Dibenz[b,e]azepine,6-(4-methyl-1-piperazinyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Perlapine

Use of Perlapine

Names

Perlapine Biological Activity

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CHEMICAL IDENTIFICATION

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ACUTE TOXICITY DATA

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Precursor & DownStream

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