Perlapine

• 常用名: Perlapine
• 英文名: Perlapine
• CAS号: 1977-11-3
• 分子量: 291.39000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₁N₃
• 熔点: N/A
• 闪点: N/A

Perlapine用途

Perlapine是一种强效毒蕈碱受体(专由设计药物激活的设计受体)激动剂Perlapine对hM3Dq的选择性是hM3受体的10000倍以上[1]。

Perlapine名称

• 英文名: 6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine

Perlapine生物活性

• 描述: Perlapine是一种强效毒蕈碱受体(专由设计药物激活的设计受体)激动剂Perlapine对hM3Dq的选择性是hM3受体的10000倍以上[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Chen X, et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.

Perlapine物理化学性质

• 分子式: C₁₉H₂₁N₃
• 分子量: 291.39000
• 精确质量: 291.17400
• PSA: 18.84000
• LogP: 2.22790
• InChIKey: PWRPUAKXMQAFCJ-UHFFFAOYSA-N
• SMILES: CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1
• 蒸汽压: 7.74E-08mmHg at 25°C

Perlapine毒性和生态

Perlapine靶点实验

查看更多实验

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa... 来源：824 靶标：AR protein [Homo sapiens] External Id：MDAN535

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign... 来源：824 靶标：N/A External Id：MDAV150

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel... 来源：824 靶标：RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein External Id：ELG271

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：thyroid hormone receptor beta isoform 2 [Rattus norvegicus] External Id：TRN186

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：N/A External Id：TRV455

实验名称：Biochemical firefly luciferase enzyme assay for NPC 来源：NCGC 靶标：Luciferase [Photinus pyralis] External Id：adst-fluc-km-fda-o1_regid

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Perlapine英文别名

• 6-(4-Methyl-1-piperazinyl)morphanthridine
• Perlapina [Spanish]
• Perlapinum [INN-Latin]
• 6-(4-Methyl-1-piperazinyl)-morphanthridin
• Hypnodin
• AW-14'2333
• 6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine
• Morphanthridine,6-(4-methyl-1-piperazinyl)
• Perlapin
• Perlapina [INN-Spanish]
• MP-11
• 6-(4-Methyl-piperazin-1-yl)-morphanthridin
• PERLAPINE