10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine
![10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine Structure](https://image.chemsrc.com/caspic/036/1982-37-2.png)
10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine structure
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Common Name | 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine | ||
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| CAS Number | 1982-37-2 | Molecular Weight | 296.43000 | |
| Density | 1.185 g/cm3 | Boiling Point | 430.4ºC at 760 mmHg | |
| Molecular Formula | C18H20N2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 214.1ºC | |
Use of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazineMethdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2]. |
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| Related Catalog | |
| Target |
MIC: 5-15 μg/mL (mycobacterium) |
| In Vitro | Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL[1]. Cell Proliferation Assay[1] Cell Line: mycobacterium: M. smegmatis 798/1546, M.,fortuitum 1529, M. scrofulaceum 1323, M. gordonae 1324, M. rnarinum 50, M.,flavescens 1541, M. terrae 1450, M. tuberculosis, H37Ra 16, H37Rv 16, K1, K2, ICRC bacillus,'Skinsnes' bacillus. Concentration: 0-20 μg/mL approximately Incubation Time: 18 h Result: Inhibited mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL. |
| In Vivo | Methdilazine (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice[1]. Methdilazine (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice[2]. Animal Model: H37Rv infected mice[1] Dosage: 10 μg/gm body wt/day, 6 weeks Administration: Intraperitoneal injection Result: Displayed an anti-mycobacterial activity to mycobacteria. Animal Model: Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice[2] Dosage: 10 mg/kg per day for 28 days Administration: Oral administration Result: Increased surviving time to 28 days with no sign of disease, showed 71.42% survival. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.185 g/cm3 |
|---|---|
| Boiling Point | 430.4ºC at 760 mmHg |
| Molecular Formula | C18H20N2S |
| Molecular Weight | 296.43000 |
| Flash Point | 214.1ºC |
| Exact Mass | 296.13500 |
| PSA | 31.78000 |
| LogP | 4.24390 |
| InChIKey | HTMIBDQKFHUPSX-UHFFFAOYSA-N |
| SMILES | CN1CCC(CN2c3ccccc3Sc3ccccc32)C1 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2934300000 |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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10-[(1-methylpy... CAS#:1982-37-2 |
| Literature: Journal of Organic Chemistry, , vol. 26, p. 1529 - 1530 |
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10-[(1-methylpy... CAS#:1982-37-2 |
| Literature: Arzneimittel Forschung, , vol. 9, p. 715 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934300000 |
|---|---|
| Summary | 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: ULK1_INH_LUMI_1536_1X%INH PRUN
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Name: Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4651404
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Name: In Vitro Protease Cleavage Assay from US Patent US9504692: "Selective inhibition of M...
Source: BindingDB
Target: N/A
External Id: BindingDB_8583_1
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Name: Selectivity index, ratio of CC50 for BHK cells to IC50 for Chikungunya virus LR2006 O...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4178822
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine |
| Tacazyl |
| 10-(1-methyl-pyrrolidin-3-ylmethyl)-phenothiazine |
| 10-(1-Methyl-pyrrolidin-3-ylmethyl)-phenothiazin |
| 10-<1-Methyl-pyrrolidinyl-(3)-methyl>-phenothiazin. |
| methdilazine |
| Methdilazinum |
| Metodilazina |
| Tacryl |
| Methodilazine |
| Methdilazinum [INN-Latin] |
| Disyncram |
| Tacaryl |
| Metodilazina [INN-Spanish] |
| 10-(1-methyl-pyrrolidin-3-ylmethyl)-10H-phenothiazine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: Polar surface area (PSA) of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is 31.78000. |
| Q: What are the uses of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: Main uses of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine: Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2]. |
| Q: What is the LogP of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: LogP of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is 4.24390. |
| Q: What is the boiling point of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: Boiling point of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is 430.4ºC at 760 mmHg. |
| Q: What is the molecular formula of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: Molecular formula of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is C18H20N2S. |
| Q: What is the CAS number of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: CAS number of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is 1982-37-2. |
| Q: What is the molecular weight of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: Molecular weight of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is 296.43000. |
| Q: What is the InChIKey of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: InChIKey of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is HTMIBDQKFHUPSX-UHFFFAOYSA-N. |
| Q: What is the English name of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: The English name of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine. |
| Q: What is the SMILES notation of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine? |
| A: SMILES notation of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine is CN1CCC(CN2c3ccccc3Sc3ccccc32)C1. |