Ethosuximide-d5

Modify Date: 2024-01-05 17:40:09

Ethosuximide-d5 Structure
Ethosuximide-d5 structure
Common Name Ethosuximide-d5
CAS Number 1989660-59-4 Molecular Weight 146.20
Density 1.1±0.1 g/cm3 Boiling Point 265.3±9.0 °C at 760 mmHg
Molecular Formula C7H6D5NO2 Melting Point N/A
MSDS N/A Flash Point 123.8±18.9 °C

 Use of Ethosuximide-d5


Ethosuximide-d5 is deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic drug, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

 Names

Name Ethosuximide-d5
Synonym More Synonyms

 Ethosuximide-d5 Biological Activity

Description Ethosuximide-d5 is deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic drug, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Chen X, et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51.

[3]. Sondossi K, et al. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28(5):512-8.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 265.3±9.0 °C at 760 mmHg
Molecular Formula C7H6D5NO2
Molecular Weight 146.20
Flash Point 123.8±18.9 °C
Exact Mass 146.110367
LogP 0.38
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.451

 Synonyms

2,5-Pyrrolidinedione, 3-(ethyl-d5)-3-methyl-
3-(2H5)Ethyl-3-methyl-2,5-pyrrolidinedione
Ethosuximide-d5