Solidagonic acid

Modify Date: 2024-01-14 12:49:21

Solidagonic acid structure	Common Name	Solidagonic acid
	CAS Number	19941-91-4	Molecular Weight	362.503
	Density	1.1±0.1 g/cm3	Boiling Point	464.9±28.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	150.9±17.5 °C

Use of Solidagonic acid

Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam[1][2].

Name	(2E)-5-[(1R,2S,3R,4aR,8aR)-3-Acetoxy-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenyl]-3-methyl-2-pentenoic acid
Synonym	More Synonyms

Description	Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin Signaling Pathways >> Cytoskeleton >> Kinesin
References	[1]. Naoaki Kurisawa, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28(1):115154. [2]. Hisashi Kato-Noguchi, et al. Allelopathy and Allelochemicals of Solidago canadensis L. and S. altissima L. for Their Naturalization. Plants (Basel). 2022 Nov 25;11(23):3235.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin

Signaling Pathways >> Cytoskeleton >> Kinesin

References

[1]. Naoaki Kurisawa, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28(1):115154.

[2]. Hisashi Kato-Noguchi, et al. Allelopathy and Allelochemicals of Solidago canadensis L. and S. altissima L. for Their Naturalization. Plants (Basel). 2022 Nov 25;11(23):3235.

Density	1.1±0.1 g/cm3
Boiling Point	464.9±28.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₄O₄
Molecular Weight	362.503
Flash Point	150.9±17.5 °C
Exact Mass	362.245697
LogP	6.49
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.518

2-Pentenoic acid, 5-[(1R,2S,3R,4aR,8aR)-3-(acetyloxy)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl]-3-methyl-, (2E)-

(2E)-5-[(1R,2S,3R,4aR,8aR)-3-Acetoxy-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenyl]-3-methyl-2-pentenoic acid

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Product Name: Solidagonic acid
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Purity: 98.0%
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