N-Arachidonoyl dopamine

Modify Date: 2025-08-26 18:26:12

N-Arachidonoyl dopamine structure	Common Name	N-Arachidonoyl dopamine
	CAS Number	199875-69-9	Molecular Weight	439.630
	Density	1.0±0.1 g/cm3	Boiling Point	640.0±55.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₄₁NO₃	Melting Point	N/A
	MSDS	USA	Flash Point	340.8±31.5 °C

Use of N-Arachidonoyl dopamine

N-Arachidonyldopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM[1]. N-Arachidonyldopamine is also a potent and selective TRPV1 agonist an with EC50 of ~ 50 nM[2].

Name	(5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide
Synonym	More Synonyms

Description	N-Arachidonyldopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM[1]. N-Arachidonyldopamine is also a potent and selective TRPV1 agonist an with EC50 of ~ 50 nM[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1:250 nM (Ki) TRPV1:~50 nM (EC50)
References	[1]. Bisogno T, et al. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem J. 2000 Nov 1;351 Pt 3(Pt 3):817-24. [2]. Huang SM, et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8400-5.

Density	1.0±0.1 g/cm3
Boiling Point	640.0±55.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₁NO₃
Molecular Weight	439.630
Flash Point	340.8±31.5 °C
Exact Mass	439.308655
PSA	69.56000
LogP	7.07
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.546
InChIKey	MVVPIAAVGAWJNQ-DOFZRALJSA-N
SMILES	CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCc1ccc(O)c(O)c1

Hazard Codes	F,Xi
Risk Phrases	R11
Safety Phrases	S16
RIDADR	UN 1170 3/PG 2

Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262

Name: Selectivity ratio of Ki for CB2 receptor of rat spleen to Ki for CB1 receptor of rat ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3239849

Name: Antiproliferative activity against rat RBL2H3 cells at 0.1 uM treated 1 hr before LPS...
Source: ChEMBL
Target: RBL-2H3
External Id: CHEMBL988014

Name: Antiproliferative activity against mouse RAW264.7 cells at 10 uM after 48 hrs relativ...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL988013

Name: Antiproliferative activity against rat RBL2H3 cells at 10 uM treated 1 hr before LPS-...
Source: ChEMBL
Target: RBL-2H3
External Id: CHEMBL988016

Name: Antiproliferative activity against rat RBL2H3 cells at 1 uM treated 1 hr before LPS-c...
Source: ChEMBL
Target: RBL-2H3
External Id: CHEMBL988015

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: qHTS for Inhibitors of Polymerase Kappa
Source: NCGC
Target: DNA polymerase kappa [Homo sapiens]
External Id: PolK100

Name: Tested for percent immobility time in the ring test, expressed as % of control (p<0.0...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL787638

Name: Human TRPV1 (Transient Receptor Potential channels)
Source: IUPHAR-DB
Target: TRPV1 (Transient Receptor Potential channels) [Homo sapiens]
External Id: 507_Human

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N-Arachidonoyl dopamine

N-Arachidonyl dopamine

Arachidonoyl dopamine

NADA

N-arachidonoyldopamine

Arachidonyl dopamine

AA-DA

(5Z,8Z,11Z,14Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-5,8,11,14-icosatetraenamide

(5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide

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Product Name: N-Arachidonoyl Dopamine
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Names

N-Arachidonoyl dopamine Biological Activity

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Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.