N-Arachidonoyl Dopamine

• 常用名: N-Arachidonoyl Dopamine
• 英文名: N-Arachidonoyl dopamine
• CAS号: 199875-69-9
• 分子量: 439.630
• 密度: 1.0±0.1 g/cm3
• 沸点: 640.0±55.0 °C at 760 mmHg
• 分子式: C₂₈H₄₁NO₃
• 熔点: N/A
• 闪点: 340.8±31.5 °C

N-Arachidonoyl Dopamine用途

花生四烯酸多巴胺是一种有效且选择性的内源性CB1受体激动剂,Ki为250 nM【1】。花生四烯酸多巴胺也是一种有效且选择性的TRPV1激动剂an,其EC50约为50 nM【2】。

N-Arachidonoyl Dopamine名称

• 中文名: NADA(N-花生四烯胺)
• 英文名: (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide

N-Arachidonoyl Dopamine生物活性

• 描述: 花生四烯酸多巴胺是一种有效且选择性的内源性CB1受体激动剂,Ki为250 nM【1】。花生四烯酸多巴胺也是一种有效且选择性的TRPV1激动剂an,其EC50约为50 nM【2】。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 靶点实验:

  CB1:250 nM (Ki)

  TRPV1:~50 nM (EC50)

• 参考文献:

  [1]. Bisogno T, et al. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem J. 2000 Nov 1;351 Pt 3(Pt 3):817-24.

  [2]. Huang SM, et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8400-5.

N-Arachidonoyl Dopamine物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 640.0±55.0 °C at 760 mmHg
• 分子式: C₂₈H₄₁NO₃
• 分子量: 439.630
• 闪点: 340.8±31.5 °C
• 精确质量: 439.308655
• PSA: 69.56000
• LogP: 7.07
• InChIKey: MVVPIAAVGAWJNQ-DOFZRALJSA-N
• SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCc1ccc(O)c(O)c1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.546
• 储存条件: -20°C，密闭，干燥

N-Arachidonoyl Dopamine安全信息

• 危害码 (欧洲): F,Xi
• 风险声明 (欧洲): R11
• 安全声明 (欧洲): S16
• 危险品运输编码: UN 1170 3/PG 2

N-Arachidonoyl Dopamine靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Selectivity ratio of Ki for CB2 receptor of rat spleen to Ki for CB1 receptor of rat ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3239849

实验名称：Antiproliferative activity against rat RBL2H3 cells at 0.1 uM treated 1 hr before LPS... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL988014

实验名称：Antiproliferative activity against mouse RAW264.7 cells at 10 uM after 48 hrs relativ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL988013

实验名称：Antiproliferative activity against rat RBL2H3 cells at 10 uM treated 1 hr before LPS-... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL988016

实验名称：Antiproliferative activity against rat RBL2H3 cells at 1 uM treated 1 hr before LPS-c... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL988015

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Tested for percent immobility time in the ring test, expressed as % of control (p<0.0... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL787638

实验名称：Human TRPV1 (Transient Receptor Potential channels) 来源：IUPHAR-DB 靶标：TRPV1 (Transient Receptor Potential channels) [Homo sapiens] External Id：507_Human

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N-Arachidonoyl Dopamine英文别名

• N-Arachidonoyl dopamine
• N-Arachidonyl dopamine
• Arachidonoyl dopamine
• NADA
• N-arachidonoyldopamine
• Arachidonyl dopamine
• AA-DA
• (5Z,8Z,11Z,14Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-5,8,11,14-icosatetraenamide
• (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide