SKF 38393 hydrobromide

Modify Date: 2024-01-12 12:10:33

SKF 38393 hydrobromide structure	Common Name	SKF 38393 hydrobromide
	CAS Number	20012-10-6	Molecular Weight	336.22400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈BrNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SKF 38393 hydrobromide

SKF 38393 hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

Name	7,8-Dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrobromide
Synonym	More Synonyms

Description	SKF 38393 hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor:110 nM (IC50)
In Vitro	SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2]. SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2]. Western Blot Analysis[2] Cell Line: GC cells Concentration: 10 μM Incubation Time: 1 hour Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
In Vivo	SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3]. SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3]. SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3]. SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4]. Animal Model: Balb/c mice (20-25 g)[3] Dosage: 5 mg/kg, 10 mg/kg Administration: Intraperitoneal injection Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
References	[1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222. [2]. Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84(1):257-64. [3]. Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892(2):241-7. [4]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70.

Molecular Formula	C₁₆H₁₈BrNO₂
Molecular Weight	336.22400
Exact Mass	335.05200
PSA	52.49000
LogP	3.66230

SKF 38393 hydrobromide

(±)-SKF 38393 hydrobromide

SKF 38393

(±)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide

(+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide

7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

(+)-Muscarine iodide

DC Chemicals Limited
China
Product Name: SKF 38393
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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