SKF 82958 hydrobromide
Modify Date: 2024-01-03 18:01:37
SKF 82958 hydrobromide structure
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Common Name | SKF 82958 hydrobromide | ||
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| CAS Number | 74115-01-8 | Molecular Weight | 410.73300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21BrClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SKF 82958 hydrobromideSKF 82958 hydrobromide is a D1/D5 receptor full agonist. IC50 value:Target: D1/D5 receptorin vitro: Neuropeptide and immediate early gene expression in striatonigral neurons of the normosensitive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and preprodynorphin (PPD) and substance P (SP) gene expression in medium spiny neurons in the dorsal, and especially, in the ventral striatum. in vivo:Quantitative in situ hybridization was used to examine the contribution of muscarinic receptors to the transynaptic regulation of striatal gene expression induced by D1receptor activation. The acute injection of the full D1 agonist, SKF-82958, would induce PPD, SP and PPE mRNA expression in the intact rat striatum. |
| Name | 3-allyl-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide |
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| Synonym | More Synonyms |
| Description | SKF 82958 hydrobromide is a D1/D5 receptor full agonist. IC50 value:Target: D1/D5 receptorin vitro: Neuropeptide and immediate early gene expression in striatonigral neurons of the normosensitive striatum is induced by mixed D1 receptor SKF-82958, which induces behavioral activity and preprodynorphin (PPD) and substance P (SP) gene expression in medium spiny neurons in the dorsal, and especially, in the ventral striatum. in vivo:Quantitative in situ hybridization was used to examine the contribution of muscarinic receptors to the transynaptic regulation of striatal gene expression induced by D1receptor activation. The acute injection of the full D1 agonist, SKF-82958, would induce PPD, SP and PPE mRNA expression in the intact rat striatum. |
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| Related Catalog | |
| References |
| Molecular Formula | C19H21BrClNO2 |
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| Molecular Weight | 410.73300 |
| Exact Mass | 409.04400 |
| PSA | 43.70000 |
| LogP | 4.82320 |
| Storage condition | 2-8℃ |
| 6-chloro-N-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-[1H]-3-benzazepine hydrobromide |
| (+/-)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide |
| (±)-chloro-APB hydrobromide |
| chloro-APB hydrobromide |
| (±)-SKF-82958 hydrobromide |
| SKF 82958 hydrobromide |
| 3-Allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol |
| hydrobromide |
| SKF-82958 (hydrobromide) |