n6-methyl-2'-deoxy-adenosine
n6-methyl-2'-deoxy-adenosine structure
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Common Name | n6-methyl-2'-deoxy-adenosine | ||
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| CAS Number | 2002-35-9 | Molecular Weight | 265.27 | |
| Density | 1.72g/cm3 | Boiling Point | 603.6ºC at 760mmHg | |
| Molecular Formula | C11H15N5O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 318.8ºC | |
Use of n6-methyl-2'-deoxy-adenosineN-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.72g/cm3 |
|---|---|
| Boiling Point | 603.6ºC at 760mmHg |
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.27 |
| Flash Point | 318.8ºC |
| Exact Mass | 265.11700 |
| PSA | 105.32000 |
| Appearance of Characters | Powder | White to Off-white |
| Vapour Pressure | 2.03E-15mmHg at 25°C |
| Index of Refraction | 1.78 |
| InChIKey | DYSDOYRQWBDGQQ-XLPZGREQSA-N |
| SMILES | CNc1ncnc2c1ncn2C1CC(O)C(CO)O1 |
| Storage condition | −20°C |
| Water Solubility | Soluble in water |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29349990 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~78%
n6-methyl-2'-de... CAS#:2002-35-9 |
| Literature: Helvetica Chimica Acta, , vol. 69, p. 1034 - 1040 |
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~31%
n6-methyl-2'-de... CAS#:2002-35-9
Detail
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| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2787 - 2792 |
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~21%
n6-methyl-2'-de... CAS#:2002-35-9
Detail
Learn More
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| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1327 - 1330 |
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~%
n6-methyl-2'-de... CAS#:2002-35-9 |
| Literature: Collection of Czechoslovak Chemical Communications, , vol. 59, # 10 p. 2303 - 2330 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
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| DownStream 2 | |
CAS#:98056-69-0This table lists relevant public references with title, journal and publication metadata for this compound.
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Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
Br. J. Pharmacol. 171(14) , 3404-19, (2014) Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood.We compared ... |
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GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat.
Neurosci. Lett. 584 , 168-72, (2014) We examined ATP-induced intracellular Ca(2+) ([Ca(2+)]i) responses in the neurons and satellite cells from one of the viscerosensory ganglia, the nodose ganglion (NG), as well as the GABA-mediated mod... |
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Pharmacological characterization of the human P2Y13 receptor.
Mol. Pharmacol. 64 , 104-112, (2003) The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi and responsivene... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| N-6-methyl-2'-deoxyribofuranosil adenine |
| N6-Methyl-2'-desoxy-adenosin |
| N6-Methyldeoxyadenosine |
| 2'-Deoxy-N6-methylado |
| Adenosine,2'-deoxy-N-methyl |
| N6-Methyl-2'-deoxyadenosine |
| 2'-deoxy-N6-methyladenosine |
| N6-methyl-2'-deoxy-adenosine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the storage conditions for (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Storage conditions for (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol: −20°C. |
| Q: What are the uses of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Main uses of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol: N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
| Q: What is the molecular formula of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Molecular formula of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol is C11H15N5O3. |
| Q: What is the SMILES notation of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: SMILES notation of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol is CNc1ncnc2c1ncn2C1CC(O)C(CO)O1. |
| Q: What are the downstream products of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Related downstream products(CAS) of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol: 443-72-1;98056-69-0. |
| Q: How is the water solubility of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Water solubility of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol: Soluble in water. |
| Q: What is the polar surface area (PSA) of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Polar surface area (PSA) of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol is 105.32000. |
| Q: What is the molecular weight of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: Molecular weight of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol is 265.27. |
| Q: What English synonyms does (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol have? |
| A: English synonyms of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol: N-6-methyl-2'-deoxyribofuranosil adenine, N6-Methyl-2'-desoxy-adenosin, N6-Methyldeoxyadenosine, 2'-Deoxy-N6-methylado, Adenosine,2'-deoxy-N-methyl, N6-Methyl-2'-deoxyadenosine, 2'-deoxy-N6-methyladenosine, N6-methyl-2'-deoxy-adenosine. |
| Q: What is the English name of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol? |
| A: The English name of (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol is (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |