DRF-1042

Modify Date: 2025-08-27 11:27:36

DRF-1042 structure	Common Name	DRF-1042
	CAS Number	200619-13-2	Molecular Weight	408.404
	Density	1.5±0.1 g/cm3	Boiling Point	844.6±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₀N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	464.6±34.3 °C

Use of DRF-1042

DRF-1042 is an orally active camptothecin analog, which acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines[1][2].

Name	drf-1042
Synonym	More Synonyms

Description	DRF-1042 is an orally active camptothecin analog, which acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Chatterjee A, et al. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novelcamptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60. [2]. Sriram Rajagopal, et al. Preclinical evaluation of the anticancer activity of DRF-1042, a novel camptothecin analog targeting Topoisomerase-I. Published April 2004.

Description

DRF-1042 is an orally active camptothecin analog, which acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

References

[1]. Chatterjee A, et al. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novelcamptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60.

[2]. Sriram Rajagopal, et al. Preclinical evaluation of the anticancer activity of DRF-1042, a novel camptothecin analog targeting Topoisomerase-I. Published April 2004.

Density	1.5±0.1 g/cm3
Boiling Point	844.6±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₀N₂O₆
Molecular Weight	408.404
Flash Point	464.6±34.3 °C
Exact Mass	408.132141
PSA	110.88000
LogP	0.60
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.726

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-12-(2-hydroxyethoxy)-, (4S,12S)-

(4S,12S)-4-Ethyl-4-hydroxy-12-(2-hydroxyethoxy)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

5-(2'-Hydroxyethoxy)-20(S)-camptothecin

1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-12-(2-hydroxyethoxy)-,(4S)

UNII-461WVF206P

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DRF-1042

Use of DRF-1042

Names

DRF-1042 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.