DRF-1042

Modify Date: 2025-08-27 11:27:36

DRF-1042 structure	Common Name	DRF-1042
	CAS Number	200619-13-2	Molecular Weight	408.404
	Density	1.5±0.1 g/cm3	Boiling Point	844.6±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₀N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	464.6±34.3 °C

Use of DRF-1042

DRF-1042 is an orally active camptothecin analog, which acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines[1][2].

Name	drf-1042
Synonym	More Synonyms

Description	DRF-1042 is an orally active camptothecin analog, which acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Chatterjee A, et al. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novelcamptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60. [2]. Sriram Rajagopal, et al. Preclinical evaluation of the anticancer activity of DRF-1042, a novel camptothecin analog targeting Topoisomerase-I. Published April 2004.

Description

DRF-1042 is an orally active camptothecin analog, which acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

References

[1]. Chatterjee A, et al. Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novelcamptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60.

[2]. Sriram Rajagopal, et al. Preclinical evaluation of the anticancer activity of DRF-1042, a novel camptothecin analog targeting Topoisomerase-I. Published April 2004.

Density	1.5±0.1 g/cm3
Boiling Point	844.6±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₀N₂O₆
Molecular Weight	408.404
Flash Point	464.6±34.3 °C
Exact Mass	408.132141
PSA	110.88000
LogP	0.60
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.726

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-12-(2-hydroxyethoxy)-, (4S,12S)-

(4S,12S)-4-Ethyl-4-hydroxy-12-(2-hydroxyethoxy)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

5-(2'-Hydroxyethoxy)-20(S)-camptothecin

1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-12-(2-hydroxyethoxy)-,(4S)

UNII-461WVF206P

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DRF-1042
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Purity: 98.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.