Ac-RYYRIK-NH2 TFA

Modify Date: 2025-08-26 12:57:05

Ac-RYYRIK-NH2 TFA structure	Common Name	Ac-RYYRIK-NH2 TFA
	CAS Number	200959-48-4	Molecular Weight	939.115
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₄H₇₀N₁₄O₉	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Ac-RYYRIK-NH2 TFA

Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].

Name	Ac-RYYRIK-NH2
Synonym	More Synonyms

Description	Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Kd: 1.5 nM (ORL1 transfected in CHO cells)[1]
In Vivo	Ac-RYYRIK-NH2 (intracerebroventricularly (i.c.v.) inhibits spontaneous locomotor activity in mice with an ID50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice[1].
References	[1]. H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8. [2]. H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9. [3]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₄H₇₀N₁₄O₉
Molecular Weight	939.115
Exact Mass	938.545044
PSA	407.97000
LogP	-1.04
Index of Refraction	1.644
InChIKey	WBBBVZGQADABSU-RERZDIOCSA-N
SMILES	CCC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCN=C(N)N)NC(C)=O)C(=O)NC(CCCCN)C(N)=O
Storage condition	-20°C

Name: Agonist activity at ORL1-Galpha fusion receptor in ICR mouse vas deferens assessed as...
Source: ChEMBL
Target: Nociceptin receptor
External Id: CHEMBL930559

Name: Agonist activity at rat Galpha-fused ORL1 receptor at 10 uM by [35S]GTPgammaS binding...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1943426

Name: Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cells
Source: ChEMBL
Target: Nociceptin receptor
External Id: CHEMBL930555

Name: Displacement of [3H]nociceptin from rat Galpha-fused ORL1 receptor expressed in afric...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1943428

Name: Activity at human ORL1-Galpha fusion receptor in COS7 cells assessed as stimulation o...
Source: ChEMBL
Target: Nociceptin receptor
External Id: CHEMBL930556

Name: Activity at human ORL1-Galpha fusion receptor in COS7 cells assessed as stimulation o...
Source: ChEMBL
Target: Nociceptin receptor
External Id: CHEMBL930557

Name: Partial agonist activity at human ORL1 receptor expressed in African green monkey COS...
Source: ChEMBL
Target: Nociceptin receptor
External Id: CHEMBL3389400

Name: Human NOP receptor (Opioid receptors)
Source: IUPHAR-DB
Target: NOP receptor (Opioid receptors) [Homo sapiens]
External Id: 320_Human

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N-acetyl-N-(diaminomethylidene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylidene)-L-ornithyl-L-isoleucyl-L-lysinamide

Ac-RYYRIK amide

AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2

N-Acetyl-N-(diaminomethylene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylene)-L-ornithyl-L-isoleucyl-L-lysinamide

ACETYL-RYYRIK,AMIDE

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China
Product Name: Ac-RYYRIK-NH2 TFA
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Purity: 98.0%
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GL Biochem (Shanghai) Ltd.
China
Product Name: Ac-RYYRIK-NH2
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

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Ac-RYYRIK-NH2 TFABioassay

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.