Ac-RYYRIK-NH2 TFA

Modify Date: 2025-08-26 12:57:05

Ac-RYYRIK-NH2 TFA structure	Common Name	Ac-RYYRIK-NH2 TFA
	CAS Number	200959-48-4	Molecular Weight	939.115
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₄H₇₀N₁₄O₉	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Ac-RYYRIK-NH2 TFA

Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].

Name	Ac-RYYRIK-NH2
Synonym	More Synonyms

Description	Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Kd: 1.5 nM (ORL1 transfected in CHO cells)[1]
In Vivo	Ac-RYYRIK-NH2 (intracerebroventricularly (i.c.v.) inhibits spontaneous locomotor activity in mice with an ID50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice[1].
References	[1]. H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8. [2]. H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9. [3]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₄H₇₀N₁₄O₉
Molecular Weight	939.115
Exact Mass	938.545044
PSA	407.97000
LogP	-1.04
Index of Refraction	1.644
Storage condition	-20°C

L-Lysinamide, N-acetyl-N-(diaminomethylene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylene)-L-ornithyl-L-isoleucyl-

N-acetyl-N-(diaminomethylidene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylidene)-L-ornithyl-L-isoleucyl-L-lysinamide

Ac-RYYRIK amide

AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2

N-Acetyl-N-(diaminomethylene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylene)-L-ornithyl-L-isoleucyl-L-lysinamide

ACETYL-RYYRIK,AMIDE

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ac-RYYRIK-NH2 TFA
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: Ac-RYYRIK-NH2
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

DC Chemicals Limited
China
Product Name: Ac-RYYRIK-NH2
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Nanjing Peptide Biotech Ltd
China
Product Name: Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

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Ac-RYYRIK-NH2 TFA

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