Ac-RYYRIK-NH2 TFA

Modify Date: 2024-01-03 13:20:30

Ac-RYYRIK-NH2 TFA structure	Common Name	Ac-RYYRIK-NH2 TFA
	CAS Number	200959-48-4	Molecular Weight	939.115
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₄H₇₀N₁₄O₉	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Ac-RYYRIK-NH2 TFA

Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].

Name	Ac-RYYRIK-NH2
Synonym	More Synonyms

Description	Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Kd: 1.5 nM (ORL1 transfected in CHO cells)[1]
In Vivo	Ac-RYYRIK-NH2 (intracerebroventricularly (i.c.v.) inhibits spontaneous locomotor activity in mice with an ID50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice[1].
References	[1]. H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8. [2]. H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9. [3]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₄H₇₀N₁₄O₉
Molecular Weight	939.115
Exact Mass	938.545044
PSA	407.97000
LogP	-1.04
Index of Refraction	1.644
Storage condition	-20°C