ER-27319

Modify Date: 2024-01-11 21:43:30

ER-27319 structure	Common Name	ER-27319
	CAS Number	201010-95-9	Molecular Weight	370.40
	Density	1.149g/cm3	Boiling Point	475.894ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₂N₂O₅	Melting Point	N/A
	MSDS	USA	Flash Point	241.613ºC

Use of ER-27319

ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].

Name	3,4-Dimethyl-10-(3-aminopropyl)-9-acridone oxalate
Synonym	More Synonyms

Description	ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Inflammation/Immunology
Target	10 μM (Syk) in human and rat mast cells[1]
References	[1]. Katsuhiro Moriya, et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23): 12539–12544. [2]. Yoshitaka Sato, et al. IgG-mediated signal transduction in canine mastocytoma-derived cells. Int Arch Allergy Immunol. 2002 Dec;129(4):305-13.

Density	1.149g/cm3
Boiling Point	475.894ºC at 760 mmHg
Molecular Formula	C₂₀H₂₂N₂O₅
Molecular Weight	370.40
Flash Point	241.613ºC
Exact Mass	396.16900
PSA	122.62000
LogP	3.53240
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.611

3,4-Hexanediol,3,4-dimethyl-1,6-diphenyl

3,4-dimethyl-1,6-diphenyl-3,4-hexanediol

ER-27319

Use of ER-27319

Names

ER-27319 Biological Activity

Chemical & Physical Properties

Synonyms