4-PPBP maleate

Modify Date: 2026-07-16 20:49:59

4-PPBP maleate structure	Common Name	4-PPBP maleate
	CAS Number	201216-39-9	Molecular Weight	409.518
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4-PPBP maleate

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons[3].
In Vivo	4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats[2]. Animal Model: Male rats weighing 300 to 385 g (Transient focal ischemia model)[2] Dosage: 1 μmol/kg Administration: Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion. Result: Decreased brain injury after transient focal ischemia in rats.
References	[1]. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. [2]. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. [3]. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula	C₂₅H₃₁NO₄
Molecular Weight	409.518
Exact Mass	409.225311

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-but-2-enedioate (1:1)

4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)

Piperidine, 4-phenyl-1-(4-phenylbutyl)-, (2Z)-2-butenedioate (1:1)

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)?

A: CAS number of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1) is 201216-39-9.

Q: What are the uses of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)?

A: Main uses of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1): 4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

Q: What is the English name of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)?

A: The English name of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1) is 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1).

Q: What English synonyms does 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1) have?

A: English synonyms of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1): 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-but-2-enedioate (1:1), 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1), Piperidine, 4-phenyl-1-(4-phenylbutyl)-, (2Z)-2-butenedioate (1:1).

Q: What is the molecular weight of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)?

A: Molecular weight of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1) is 409.518.

Q: What is the molecular formula of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)?

A: Molecular formula of 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1) is C25H31NO4.

Q: What is the Chinese name of 201216-39-9?

A: Chinese name of 201216-39-9 is 4-PPBP maleate.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-PPBP maleate
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

4-PPBP maleate suppliers

4-PPBP maleate price

4-PPBP maleate

Use of 4-PPBP maleate

Names

4-PPBP maleate Biological Activity

Chemical & Physical Properties

Synonyms

4-PPBP maleate | FAQ

4-PPBP maleatefactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.