201216-39-9

201216-39-9 structure

Name: 4-PPBP maleate
Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)
CAS Number: 201216-39-9
Molecular Formula: C₂₅H₃₁NO₄
Molecular Weight: 409.518
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2018-06-21 08:22:24
Modify Date: 2024-01-04 18:47:30
4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

Name	4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)
Synonyms	4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-but-2-enedioate (1:1) 4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1) Piperidine, 4-phenyl-1-(4-phenylbutyl)-, (2Z)-2-butenedioate (1:1)

Description	4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons[3].
In Vivo	4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats[2]. Animal Model: Male rats weighing 300 to 385 g (Transient focal ischemia model)[2] Dosage: 1 μmol/kg Administration: Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion. Result: Decreased brain injury after transient focal ischemia in rats.
References	[1]. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. [2]. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. [3]. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424.

Molecular Formula	C₂₅H₃₁NO₄
Molecular Weight	409.518
Exact Mass	409.225311

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