AZ 1729
Modify Date: 2023-02-01 10:49:29
AZ 1729 structure
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Common Name | AZ 1729 | ||
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| CAS Number | 2016864-46-1 | Molecular Weight | 369.418 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16FN5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZ 1729AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways; produces stimulation of [35S]GTPγS binding with pEC50 7.23, inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils. |
| Name | AZ1729 |
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| Description | AZ1729 is a novel direct, positive allosteric modulator of fatty acid receptor FFA2 (pEC50=6.9), selectively activates Gi signaling but lacks the capacity to activate FFA2 Gq/G11-mediated signaling pathways; produces stimulation of [35S]GTPγS binding with pEC50 7.23, inhibits β-adrenoreceptor agonist-promoted lipolysis in primary mouse adipocytes and promotes chemotaxis of isolated human neutrophils. |
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| References | References 1. Bolognini D, et al. J Biol Chem. 2016 Sep 2;291(36):18915-31. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
| Molecular Formula | C18H16FN5OS |
|---|---|
| Molecular Weight | 369.418 |