Ramiprilat-d5

Modify Date: 2024-01-10 18:42:01

Ramiprilat-d5 Structure
Ramiprilat-d5 structure
Common Name Ramiprilat-d5
CAS Number 2021255-43-4 Molecular Weight 393.49
Density N/A Boiling Point N/A
Molecular Formula C21H23D5N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ramiprilat-d5


Ramiprilat-d5 is deuterium labeled Ramiprilat. Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research[1].

 Names

Name Ramiprilat-d5

 Ramiprilat-d5 Biological Activity

Description Ramiprilat-d5 is deuterium labeled Ramiprilat. Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research[1].

 Chemical & Physical Properties

Molecular Formula C21H23D5N2O5
Molecular Weight 393.49