7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid

Modify Date: 2024-01-07 19:16:00

7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid Structure
7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid structure
Common Name 7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid
CAS Number 20300-59-8 Molecular Weight 220.178
Density 1.5±0.1 g/cm3 Boiling Point 424.4±45.0 °C at 760 mmHg
Molecular Formula C11H8O5 Melting Point 194ºC
MSDS Chinese USA Flash Point 172.4±22.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid


7-Methoxycoumarin-3-carboxylic acid is a fluorescent dye with an excitation peak at 355 nm and an emission peak at 405 nm. 7-Methoxycoumarin-3-carboxylic acid can be used to label peptide[1].

 Names

Name 7-Methoxycoumarin-3-carboxylic acid
Synonym More Synonyms

  Biological Activity

Description 7-Methoxycoumarin-3-carboxylic acid is a fluorescent dye with an excitation peak at 355 nm and an emission peak at 405 nm. 7-Methoxycoumarin-3-carboxylic acid can be used to label peptide[1].
Related Catalog
In Vitro 7-Methoxycoumarin-3-carboxylic acid (compound 5) (100 µM; 72 h) shows non-toxic for K562, Daudi, RPMI-8226, and Jurkat cells with IC50s of >100, >100, >100, >100 µM, respectively[1].
References

[1]. Wiemer AJ, et al. Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group. Chembiochem. 2016 Jan 1;17(1):52-5.

[2]. Mohamed-Anis Alouini, et al. Interaction of fluorescently labeled triethyleneglycol and peptide derivatives with β-cyclodextrin. Chemphyschem. 2014 Feb 24;15(3):444-57.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 424.4±45.0 °C at 760 mmHg
Melting Point 194ºC
Molecular Formula C11H8O5
Molecular Weight 220.178
Flash Point 172.4±22.2 °C
Exact Mass 220.037170
PSA 76.74000
LogP 1.56
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.611
Storage condition -20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
HS Code 2932209090

 Synthetic Route

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles1

More Articles
Hydrophobicity of Antifungal β-Peptides Is Associated with Their Cytotoxic Effect on In Vitro Human Colon Caco-2 and Liver HepG2 Cells.

PLoS ONE 11 , e0149271, (2016)

The widespread distribution of fungal infections, with their high morbidity and mortality rate, is a global public health problem. The increase in the population of immunocompromised patients combined...

 Synonyms

7-Methoxy-2-oxo-2H-chromene-3-carboxylic acid
2H-1-Benzopyran-3-carboxylic acid, 7-methoxy-2-oxo-
7-methoxy-2-oxochromene-3-carboxylic acid