ICCB280
Modify Date: 2025-08-25 12:16:26
ICCB280 structure
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Common Name | ICCB280 | ||
|---|---|---|---|---|
| CAS Number | 2041072-41-5 | Molecular Weight | 386.400 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 624.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C23H18N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 331.2±34.3 °C | |
Use of ICCB280ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2]. |
| Name | ICCB280 |
|---|---|
| Synonym | More Synonyms |
| Description | ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2]. |
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| Related Catalog | |
| Target |
C/EBPα[1] |
| In Vitro | ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1]. ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells[1]. ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells[1]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 0.1, 0.5, 1, 5, 10, 50 μM Incubation Time: 48 hours Result: Induced cell growth arrest, with an IC50 of 8.6 μM. Western Blot Analysis[1] Cell Line: HL-60 cells Concentration: 10 μM Incubation Time: 2, 4, 6, 8 days Result: Upregulated the C/EBPα protein on day 4. Increased the C/EBPε expression on day 6. No changes in C/EBPβ expression through the 8 days of the experiment. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 624.1±65.0 °C at 760 mmHg |
| Molecular Formula | C23H18N2O4 |
| Molecular Weight | 386.400 |
| Flash Point | 331.2±34.3 °C |
| Exact Mass | 386.126648 |
| LogP | 3.89 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.644 |
| 2-[2-(3,4-Dihydroxy-phenyl)-vinyl]-3-(2-methoxy-phenyl)-3H-quinazolin-4-one |
| 4(3H)-Quinazolinone, 2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)- |