2041072-41-5

2041072-41-5 structure

Name: ICCB280
Chemical Name: ICCB280
CAS Number: 2041072-41-5
Molecular Formula: C₂₃H₁₈N₂O₄
Molecular Weight: 386.400
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-04-26 20:19:10
Modify Date: 2024-04-13 21:14:14
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2].

Name	ICCB280
Synonyms	2-[2-(3,4-Dihydroxy-phenyl)-vinyl]-3-(2-methoxy-phenyl)-3H-quinazolin-4-one 4(3H)-Quinazolinone, 2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-(2-methoxyphenyl)-

Description	ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	C/EBPα[1]
In Vitro	ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1]. ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells[1]. ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells[1]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 0.1, 0.5, 1, 5, 10, 50 μM Incubation Time: 48 hours Result: Induced cell growth arrest, with an IC50 of 8.6 μM. Western Blot Analysis[1] Cell Line: HL-60 cells Concentration: 10 μM Incubation Time: 2, 4, 6, 8 days Result: Upregulated the C/EBPα protein on day 4. Increased the C/EBPε expression on day 6. No changes in C/EBPβ expression through the 8 days of the experiment.
References	[1]. Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20(9):1150-9. [2]. Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23(8):1938.