Liraglutide

Modify Date: 2025-08-21 16:46:50

Liraglutide structure	Common Name	Liraglutide
	CAS Number	204656-20-2	Molecular Weight	3751.20000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇₂H₂₆₅N₄₃O₅₁	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Liraglutide

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

Name	liraglutide
Synonym	More Synonyms

Description	Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor Research Areas >> Metabolic Disease Peptides Peptides
Target	GLP-1 receptor[1]
In Vitro	Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1 that stimulates insulin secretion. Liraglutide is an injectable drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells[1].
Cell Assay	Raw264.7 macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination[1].
References	[1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9. [2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416.

Molecular Formula	C₁₇₂H₂₆₅N₄₃O₅₁
Molecular Weight	3751.20000
Exact Mass	3748.95000
PSA	1513.76000
LogP	6.12960
InChIKey	YSDQQAXHVYUZIW-QCIJIYAXSA-N
SMILES	CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)C(C)C)C(C)CC)C(=O)O
Storage condition	-20°C

Name: Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of b...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3112061

Name: Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of b...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3112063

Name: Anorectic activity in ICR mouse assessed as decrease in food intake at 25 nmol/kg, ip...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL5146213

Name: Antidiabetic activity in C57BL/6J-m+/+Leprdb (db/db) mouse assessed as reduction of H...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3112065

Name: Tmax in Sprague-Dawley rat at 15 nmol/kg, sc by LC-MS/MS analysis
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3110976

Name: Antidiabetic activity in Sprague-Dawley rat assessed as reduction of plasma glucose l...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3110977

Name: Antidiabetic activity in Sprague-Dawley rat assessed as increase of plasma insulin le...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3110978

Name: Antidiabetic activity in Sprague-Dawley rat assessed as increase of plasma insulin le...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3110979

Name: Binding affinity to human serum albumin at 100 ug/mL after 3 hrs relative to control
Source: ChEMBL
Target: Albumin
External Id: CHEMBL3110981

Name: Antiobesity activity in high-fat diet-induced obesity model of male C57BL/6J mouse as...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL5053325

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liraglutide

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Liraglutide

Use of Liraglutide

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Liraglutide Biological Activity

Chemical & Physical Properties

LiraglutideBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.