2(1H)-Quinolinone,7-hydroxy-4-methyl-

Modify Date: 2024-01-02 18:18:57

2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure
2(1H)-Quinolinone,7-hydroxy-4-methyl- structure
Common Name 2(1H)-Quinolinone,7-hydroxy-4-methyl-
CAS Number 20513-71-7 Molecular Weight 175.18400
Density 1.264 g/cm3 Boiling Point 417.8ºC at 760 mmHg
Molecular Formula C10H9NO2 Melting Point ≥250ºC(lit.)
MSDS Chinese USA Flash Point 206.5ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2(1H)-Quinolinone,7-hydroxy-4-methyl-


7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage[1].

 Names

Name 7-Hydroxy-4-methyl-2(1H)-quinolone
Synonym More Synonyms

 2(1H)-Quinolinone,7-hydroxy-4-methyl- Biological Activity

Description 7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage[1].
Related Catalog
References

[1]. Tang VJ, et al. DNA Binding Hydroxyl Radical Probes. Radiat Phys Chem Oxf Engl 1993. 2012 Jan;81(1):46-51.

 Chemical & Physical Properties

Density 1.264 g/cm3
Boiling Point 417.8ºC at 760 mmHg
Melting Point ≥250ºC(lit.)
Molecular Formula C10H9NO2
Molecular Weight 175.18400
Flash Point 206.5ºC
Exact Mass 175.06300
PSA 53.09000
LogP 1.54210
Vapour Pressure 1.42E-07mmHg at 25°C
Index of Refraction 1.611

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
HS Code 2933790090

 Synthetic Route

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2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Literature: Journal of Organic Chemistry, , vol. 56, # 3 p. 980 - 983

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2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

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CAS#:20513-71-7

Literature: Synthesis, , # 8 art. no. M08304SS, p. 1231 - 1233

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2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Literature: Deshmukh; Dhongade-Desai, Savita; Chavan Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 8 p. 1659 - 1662

~86%

2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Literature: Priya, Nivedita; Gupta, Anjali; Chand, Karam; Singh, Prabhjot; Kathuria, Abha; Raj, Hanumantharao G.; Parmar, Virinder S.; Sharma, Sunil K. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 4085 - 4094

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2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Literature: Tetrahedron Letters, , vol. 40, # 24 p. 4505 - 4506

~66%

2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Literature: Abd El-Aal; Koraierm Journal of the Chinese Chemical Society, 2000 , vol. 47, # 2 p. 389 - 395

~54%

2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Detail
Literature: Journal of Organic Chemistry, , vol. 56, # 3 p. 980 - 983

~%

2(1H)-Quinolinone,7-hydroxy-4-methyl- Structure

2(1H)-Quinolino...

CAS#:20513-71-7

Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 44, # 8 p. 1659 - 1662

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

 Articles2

More Articles
On the metabolism of quinoline and isoquinoline: possible molecular basis for differences in biological activities.

Carcinogenesis 4 , 1169-1173, (1983)

Quinoline is a hepatocarcinogen in mice and rats, a mutagen in Salmonella typhimurium, and induces unscheduled DNA synthesis in primary cultures of rat hepatocytes. In contrast, isoquinoline has not b...

Microbial metabolism of quinoline and related compounds. XIX. Degradation of 4-methylquinoline and quinoline by Pseudomonas putida K1.

Biol. Chem. Hoppe-Seyler 374 , 479-488, (1993)

A bacterial strain, designated K1, which utilizes 4-methylquinoline and quinoline as sole source of carbon, nitrogen and energy was isolated from soil. Based on its morphological and physiological cha...

 Synonyms

7-hydroxy-4-methyl-1H-quinolin-2-one
2,7-Dihydroxy-4-methylquinoline 7-Hydroxy-4-methylcarbostyryl