IV-361

Modify Date: 2023-02-01 15:29:07

IV-361 structure	Common Name	IV-361
	CAS Number	2055741-39-2	Molecular Weight	457.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₂FN₅O₂Si	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IV-361

IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1].

Name	IV-361

Description	IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK7:≤50 nM (Ki) CDK2:≥1000 nM (Ki)
In Vitro	IV-361 has less inhibition on CDK2 (Ki≥1000 nM) or PLK1 (Ki≥5000 nM)[1]. IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC50≤100 nM) in periphery blood mononuclear cell (PBMC)[1]. IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI50≤100 nM)[1].
In Vivo	IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1].
References	[1]. Noriaki Iwase, et al. Substituted dihydropyrrolopyrazole derivative. US20190256531A1.

Molecular Formula	C₂₃H₃₂FN₅O₂Si
Molecular Weight	457.62