IV-23

Modify Date: 2024-01-03 15:38:58

IV-23 structure	Common Name	IV-23
	CAS Number	2326007-49-0	Molecular Weight	392.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₈BrNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IV-23

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC)[1].

Name	IV-23

Description	IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC50 values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells[1]. IV-23 induces G2/M phase arrest[1].
References	[1]. Fu DJ, et al. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis. Bioorg Chem. 2019 Aug 10;92:103190.

Molecular Formula	C₁₈H₁₈BrNO₄
Molecular Weight	392.24

IV-23

Use of IV-23

Names

IV-23 Biological Activity

Chemical & Physical Properties