ALK-IN-6

Modify Date: 2024-01-03 08:14:08

ALK-IN-6 structure	Common Name	ALK-IN-6
	CAS Number	2055821-33-3	Molecular Weight	533.10
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₉D₃ClN₅O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALK-IN-6

ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1].

Name	ALK-IN-6

Description	ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	IC50: 71 nM (ALK wild), 18.72 nM (ALK F1196M), 36.81 nM (ALK F1174L)[1].
References	[1]. Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1514-1517.

Molecular Formula	C₂₆H₂₉D₃ClN₅O₃S
Molecular Weight	533.10