BD1063 (dhydrochloride)
Modify Date: 2024-01-09 04:25:31
BD1063 (dhydrochloride) structure
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Common Name | BD1063 (dhydrochloride) | ||
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| CAS Number | 206996-13-6 | Molecular Weight | 346.12300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H20Cl4N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BD1063 (dhydrochloride)BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. |
| Name | 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine |
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| Synonym | More Synonyms |
| Description | BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. |
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| Related Catalog | |
| In Vivo | BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule[1]. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity[2]. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia[3]. |
| Animal Admin | Rats: BD1063 is solubilized in isotonic saline and injected subcutaneously (s.c. 1 ml/kg), 15 min before testing. Rats are pretreated with BD1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights, s.c.) using a within-subject Latin square design. sP rats: Rats are pretreated with BD1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis, s.c.) using a within-subject Latin square design[1]. |
| References |
| Molecular Formula | C13H20Cl4N2 |
|---|---|
| Molecular Weight | 346.12300 |
| Exact Mass | 344.03800 |
| PSA | 6.48000 |
| LogP | 4.26310 |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
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A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
Mol. Pharmacol. 86(4) , 390-8, (2014) Fast excitatory synaptic transmission that is contingent upon N-methyl d-aspartate receptor (NMDAR) function contributes to core information flow in the central nervous system and to the plasticity of... |
| BD 1063 dihydrochloride |
| BD 1063 Dihydrochloride |
| 1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride BD1063 dihydrochloride |
| Tocris-0883 |
| BD1063 (dhydrochloride) |