EPZ020411 hydrochloride
Modify Date: 2024-01-13 19:02:03
EPZ020411 hydrochloride structure
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Common Name | EPZ020411 hydrochloride | ||
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| CAS Number | 2070015-25-5 | Molecular Weight | 479.06 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H39ClN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EPZ020411 hydrochlorideEPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies. |
| Name | EPZ020411 hydrochloride |
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| Description | EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies. |
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| Molecular Formula | C25H39ClN4O3 |
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| Molecular Weight | 479.06 |
| Storage condition | 2-8℃ |