Rutin hydrate
Modify Date: 2025-09-07 17:47:10
Rutin hydrate structure
|
Common Name | Rutin hydrate | ||
|---|---|---|---|---|
| CAS Number | 207671-50-9 | Molecular Weight | 664.56300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H3O16.xH2O | Melting Point | 195°C dec. (Lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Rutin hydrateRutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling. |
| Name | 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-( 6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside trihydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Rutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling. |
|---|---|
| Related Catalog | |
| Target |
JNK ERK1 ERK2 mTOR |
| In Vivo | Rutin hydrate (100 mg/kg) significantly lowers MDA levels and concomitantly increases glutathione (GSH), GSH/oxidized glutathione (GSSG) ratio, total glutathione levels and activities of GPx in the brain of rats. Rutin hydrate alone or in combination with a-tocopherol to CdCl2 intoxicated rats inhibits the declines in the levels of Ach and ChAT activity and significantly inhibited the activities of AChE. Rutin hydrate also inhibits neural apoptosis by inhibiting JNK activation in the brain of control and CdCl2 intoxicated rats and of ERK1/2 activation in the brain of CdCl2 intoxicated rats. In addition, Rutin hydrate activates mTOR/Akt in the brain of control and CdCl2 intoxicated rats[1]. |
| Animal Admin | Rats[1] (1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl2 intoxicated group receives CdCl2 at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl2 + Rutin hydrate treated group (CdCl2 + Rutin hydrate) receives CdCl2 (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl2 + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl2 (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days[1]. |
| References |
| Melting Point | 195°C dec. (Lit.) |
|---|---|
| Molecular Formula | C27H3O16.xH2O |
| Molecular Weight | 664.56300 |
| Exact Mass | 664.18500 |
| PSA | 297.12000 |
| InChIKey | PGHSKTKIQIBATG-ZAAWVBGYSA-N |
| SMILES | CC1OC(OCC2OC(Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)C(O)C(O)C2O)C(O)C(O)C1O.O |
|
The impact of drying techniques on phenolic compound, total phenolic content and antioxidant capacity of oat flour tarhana.
Food Chem. 194 , 587-94, (2015) In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying trea... |
|
|
Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base.
Molecules 20 , 9788-802, (2015) Co(II), Ni(II), Zn(II) and Cu(II) complexes of (3E)-3-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one (DEPH2) derived from ethylenediamine, 2',4'-dihydroxyacetopheno... |
|
|
Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218.
Drug Metab. Dispos. 43 , 922-7, (2015) The anthracyclines doxorubicin and daunorubicin are used in the treatment of various human and canine cancers, but anthracycline-related cardiotoxicity limits their clinical utility. The formation of ... |
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
|
|
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
|
|
Name: Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas...
Source: Broad Institute
Target: N/A
External Id: 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2
|
|
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
|
|
Name: qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima...
Source: NCGC
Target: apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7]
External Id: AMA1100
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: abhydrolase domain-containing protein 4 isoform 1 [Mus musculus]
External Id: ABHD4_INH_FP_1536_1X%INH PRUN
|
Total 90, Current Page 1 of 9
1
2
3
4
5
| Rutin hydrate |
| MFCD00149490 |
| EINECS 205-814-1 |
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Rutin hydrate
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: RUTIN HYDRATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Rutin hydrate
- Price: ￥148.0/25g ￥438.0/100g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
Get all suppliers and price by the below link:
Price: ￥500/5 g
Reference only. check more Rutin hydrate price