MA-0204
Modify Date: 2024-01-12 00:37:49
MA-0204 structure
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Common Name | MA-0204 | ||
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| CAS Number | 2095128-17-7 | Molecular Weight | 476.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H27F3N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MA-0204MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1]. |
| Name | MA-0204 |
|---|
| Description | MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1]. |
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| Related Catalog | |
| Target |
PPARδ:0.4 nM (EC50, in human) PPARδ:7.9 nM (EC50, in mouse) PPARδ:10 nM (EC50, in rat) |
| In Vitro | MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C[1]. MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice[1]. MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts[1]. |
| In Vivo | PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle[1]. |
| References |
| Molecular Formula | C25H27F3N2O4 |
|---|---|
| Molecular Weight | 476.49 |
| Storage condition | 2-8℃ |