PROTAC Sirt2 Degrader-1
Modify Date: 2024-01-17 14:51:27
PROTAC Sirt2 Degrader-1 structure
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Common Name | PROTAC Sirt2 Degrader-1 | ||
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| CAS Number | 2098487-75-1 | Molecular Weight | 852.94 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H40N10O8S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC Sirt2 Degrader-1PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1]. |
| Name | PROTAC Sirt2 Degrader-1 |
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| Description | PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1]. |
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| Related Catalog | |
| Target |
SIRT2:0.25 μM (IC50) |
| In Vitro | PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 µM Incubation Time: 1-6 hours Result: Caused Sirt2 degradation, but showed no effect on Sirt1 levels. |
| References |
| Molecular Formula | C40H40N10O8S2 |
|---|---|
| Molecular Weight | 852.94 |
| Storage condition | 2-8℃ |