PARP1-IN-14

Modify Date: 2024-04-06 16:33:03

PARP1-IN-14 structure	Common Name	PARP1-IN-14
	CAS Number	2098639-70-2	Molecular Weight	525.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₄FN₇O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PARP1-IN-14

PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].

Name	PARP1-IN-14

Description	PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP1:0.6 ± 0.1 nM (IC50)
References	[1]. Wang P, et al. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023 Nov 5;259:115709.

Molecular Formula	C₂₈H₂₄FN₇O₃
Molecular Weight	525.53

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PARP1-IN-14

Use of PARP1-IN-14

Names

PARP1-IN-14 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.