Compound E
Modify Date: 2025-08-23 22:29:38
Compound E structure
|
Common Name | Compound E | ||
|---|---|---|---|---|
| CAS Number | 209986-17-4 | Molecular Weight | 490.501 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 778.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C27H24F2N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 424.7±32.9 °C | |
Use of Compound ECompound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. |
| Name | γ-Secretase Inhibitor XXI |
|---|---|
| Synonym | More Synonyms |
| Description | Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)[1] |
| In Vitro | Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1]. |
| Cell Assay | The breast cancer cell lines MDA-MB-231, T47D, and MCF-7 are treated with Compound E at concentrations in the range 0.01-50 μM for 48 h and their viability is determined using a Coulter counter[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 778.6±60.0 °C at 760 mmHg |
| Molecular Formula | C27H24F2N4O3 |
| Molecular Weight | 490.501 |
| Flash Point | 424.7±32.9 °C |
| Exact Mass | 490.181641 |
| PSA | 90.87000 |
| LogP | 3.22 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.624 |
| InChIKey | JNGZXGGOCLZBFB-IVCQMTBJSA-N |
| SMILES | CC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O |
| Storage condition | 2-8℃ |
|
Name: Inhibition of gamma secretase-mediated amyloid beta (1 to 40) production in human SH-...
Source: ChEMBL
Target: Gamma-secretase subunit APH-1B
External Id: CHEMBL1110756
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|
Name: Inhibition of gamma secretase in human CUTLL1 cells assessed as effect on NOTCH cleav...
Source: ChEMBL
Target: Gamma-secretase subunit APH-1B
External Id: CHEMBL3372633
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|
Name: Inhibition of gamma secretase in human CUTLL1 cells assessed as effect on NOTCH cleav...
Source: ChEMBL
Target: Gamma-secretase subunit APH-1B
External Id: CHEMBL3372632
|
Total 3, Current Page 1 of 1
1
| COMPOUND E ((2S)-2-(AMINO)-N-PROPANAMIDE) |
| Gamma-Secretase Inhibitor XXI |
| Compound E |
| N-[(3,5-Difluorophenyl)acetyl]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-L-alaninamide |