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  • DC Chemicals Limited
  • China
  • Product Name: Compound E
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

209986-17-4

209986-17-4 structure
209986-17-4 structure
  • Name: Compound E
  • Chemical Name: γ-Secretase Inhibitor XXI
  • CAS Number: 209986-17-4
  • Molecular Formula: C27H24F2N4O3
  • Molecular Weight: 490.501
  • Catalog: Signaling Pathways Neuronal Signaling γ-secretase
  • Create Date: 2017-01-22 08:36:00
  • Modify Date: 2024-01-07 23:05:41
  • Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

Name γ-Secretase Inhibitor XXI
Synonyms COMPOUND E ((2S)-2-(AMINO)-N-PROPANAMIDE)
Gamma-Secretase Inhibitor XXI
Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-
Compound E
N-[(3,5-Difluorophenyl)acetyl]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-L-alaninamide
Description Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
Related Catalog
Target

IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)[1]

In Vitro Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1].
Cell Assay The breast cancer cell lines MDA-MB-231, T47D, and MCF-7 are treated with Compound E at concentrations in the range 0.01-50 μM for 48 h and their viability is determined using a Coulter counter[1].
References

[1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.

[2]. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88.

Density 1.3±0.1 g/cm3
Boiling Point 778.6±60.0 °C at 760 mmHg
Molecular Formula C27H24F2N4O3
Molecular Weight 490.501
Flash Point 424.7±32.9 °C
Exact Mass 490.181641
PSA 90.87000
LogP 3.22
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.624
Storage condition 2-8℃