1,11b-Dihydro-11b-hydroxyMedicarpin

Modify Date: 2024-01-04 07:15:23

1,11b-Dihydro-11b-hydroxyMedicarpin Structure
1,11b-Dihydro-11b-hydroxyMedicarpin structure
Common Name 1,11b-Dihydro-11b-hydroxyMedicarpin
CAS Number 210537-04-5 Molecular Weight 288.295
Density 1.4±0.1 g/cm3 Boiling Point 490.0±45.0 °C at 760 mmHg
Molecular Formula C16H16O5 Melting Point N/A
MSDS N/A Flash Point 185.8±22.2 °C

 Use of 1,11b-Dihydro-11b-hydroxyMedicarpin


1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

 Names

Name 3-(2-Methyl-1,3-benzodioxol-2-yl)propanal
Synonym More Synonyms

 1,11b-Dihydro-11b-hydroxyMedicarpin Biological Activity

Description 1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
Related Catalog
References

[1]. Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190.

[2]. Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541.

[3]. Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 490.0±45.0 °C at 760 mmHg
Molecular Formula C16H16O5
Molecular Weight 288.295
Flash Point 185.8±22.2 °C
Exact Mass 288.099762
PSA 64.99000
LogP 1.36
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.637

 Synonyms

(6aR,11aR,11bS)-11b-Hydroxy-9-methoxy-1,2,6,6a,11a,11b-hexahydro-3H-[1]benzofuro[3,2-c]chromen-3-one
3H-Benzofuro[3,2-c][1]benzopyran-3-one, 1,2,6,6a,11a,11b-hexahydro-11b-hydroxy-9-methoxy-, (6aR,11aR,11bS)-