210537-04-5

210537-04-5 structure

Name: 1,11b-Dihydro-11b-hydroxyMedicarpin
Chemical Name: 3-(2-Methyl-1,3-benzodioxol-2-yl)propanal
CAS Number: 210537-04-5
Molecular Formula: C₁₆H₁₆O₅
Molecular Weight: 288.295
Catalog: Natural product Phenols
Create Date: 2016-05-21 23:07:17
Modify Date: 2024-01-04 07:15:23
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

Name	3-(2-Methyl-1,3-benzodioxol-2-yl)propanal
Synonyms	(6aR,11aR,11bS)-11b-Hydroxy-9-methoxy-1,2,6,6a,11a,11b-hexahydro-3H-[1]benzofuro[3,2-c]chromen-3-one 3H-Benzofuro[3,2-c][1]benzopyran-3-one, 1,2,6,6a,11a,11b-hexahydro-11b-hydroxy-9-methoxy-, (6aR,11aR,11bS)-

Description	1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
References	[1]. Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190. [2]. Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. [3]. Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299.