koenimbine

Modify Date: 2026-07-14 21:29:46

koenimbine Structure
koenimbine structure
Common Name koenimbine
CAS Number 21087-98-9 Molecular Weight 293.36
Density 1.193g/cm3 Boiling Point 482.1ºC at 760 mmHg
Molecular Formula C19H19NO2 Melting Point 194-195℃
MSDS Chinese USA Flash Point 171.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of koenimbine


Koenimbine is an anticancer agent that can be obtained from the leaves and fruits of Murraya koenigii. Koenimbine can induce apoptosis and necrosis in HT-29 and SW48 cells. Koenimbine can be used in the research of cancer[1].

 Names

Name 8-methoxy-3,3,5-trimethyl-11H-pyrano[3,2-a]carbazole
Synonym More Synonyms

 koenimbine Biological Activity

Description Koenimbine is an anticancer agent that can be obtained from the leaves and fruits of Murraya koenigii. Koenimbine can induce apoptosis and necrosis in HT-29 and SW48 cells. Koenimbine can be used in the research of cancer[1].
Related Catalog
References

[1]. Astaneh M, et al. Assessment of anti-cancer effects of koenimbine on colon cancer cells. Hum Antibodies. 2020;28(3):185-190.  

 Chemical & Physical Properties

Density 1.193g/cm3
Boiling Point 482.1ºC at 760 mmHg
Melting Point 194-195℃
Molecular Formula C19H19NO2
Molecular Weight 293.36
Flash Point 171.8ºC
Exact Mass 293.14200
PSA 34.25000
LogP 4.82230
Vapour Pressure 5.5E-09mmHg at 25°C
Index of Refraction 1.658
InChIKey OSERHKINMDLESD-UHFFFAOYSA-N
SMILES COc1ccc2[nH]c3c4c(c(C)cc3c2c1)OC(C)(C)C=C4

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319-H413
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36-53
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 koenimbineBioassay

View more

Name: Inhibition of mushroom tyrosinase using L-DOPA as substrate after at 30 uM after 5 mi...
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL2329451
Name: Inhibition of mushroom tyrosinase using L-DOPA as substrate after at 100 uM after 5 m...
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL2329450
Name: Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as inducti...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3854177
Name: Metabolic stability in rat liver microsomes assessed as parent compound remaining aft...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3854178
Name: Half life in rat liver microsomes in presence of NADPH by HPLC analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL3854179
Name: Antidiabetic activity in overnight fasted STZ-induced albino Sprague-Dawley rat diabe...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3854180
Name: Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as increas...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3854173
Name: Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as increas...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3854174
Name: Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as increas...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3854175
Name: Inhibition of theophylline-induced melanogenesis in mouse B16-4A5 cells at 10 uM afte...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2329463
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 Synonyms

Koenimbin
Koenimbine
O-methyl mukonal
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